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Flutamide undergoes amide hydrolysis following administration to humans 5 but this was not recapitulated in either rat S9 incubation

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5.4 Pharmacological effects of SIN in other diseases SIN has exhibited therapeutic efficacy in various diseases, including colitis (119), atherosclerosis (120), myocardial ischemiareperfusion injury (100), chronic sciatic nerve injury (CCI) (121), renal injury (122), colorectal cancer (123), lung cancer, liver cancer, cervical cancer, bladder cancer, gastric cancer, and renal cancer (93, 124, 125)

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FEBS Lett1991 Mar 25;280(2):247-50