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However, the therapeutic utility of doxorubicin is undermined by its dose-dependent cardiotoxicity, possibly arising as a result of futile redox cycling, with NADH dehydrogenase within the mitochondria proposed as the most likely site of anthracycline reduction 9,10

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2 Literature search strategy We conducted a comprehensive literature search to identify relevant studies on the role of riboflavin in neurological diseases

Vehicle context: The worked example can use sterile 0.9% saline as a research vehicle