Importantly, the application of ferrostatin-1 successfully mitigated the ferroptosis and EMT-related dysfunctions, indicating promising pathways for therapeutic intervention ( Tumor protein p53 (TP53) , Enhancer of Zeste Homolog 2 (EZH2 ), Tissue inhibitor matrix metalloproteinase 1 (TIMP1) , Solute carrier family 3 member 2 (SLC3A2), and Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) (Table 3)
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Athletes participating in endurance disciplinessuch as long-distance running, road cycling, and swimmingfrequently present with reduced bone mineral density relative to athletes from other sports, control groups, or established population norms
doi: 10.1038/s41598-020-62463-4 59
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