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Older adults are more likely to be on multiple medications, increasing the potential for interactions

Deterioration of CD was classified according to the CD activity index (CDAI) (34), which is a composite scoring system based on selected clinical symptoms, such as the number of liquid stools, the severity of abdominal pain, general well-being, extraintestinal CD manifestations, abdominal mass, use of antidiarrheal drugs, as well as haematocrit and body weight

Although, there are available data on the development of CMD and the mechanisms associated with its attendant complications, novel mechanisms are still revealed by recent studies in an attempt to open new therapeutic opportunities [4, 5]

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Alicic RZ, Cox EJ, Neumiller JJ, Tuttle KR