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Allergic Reactions : Though rare, allergic reactions to Semaglutide can occur

Also, the comparative effectiveness of GLP1 receptor agonists and SGLT2 inhibitors has been a growing interest, and several cohort studies with robust methodology have concluded comparable dementia risk between initiators of GLP1 receptor agonists and SGLT2 inhibitors [16, 25, 26]

Our analysis indicates that there is no significant influence from unmeasured confounding variables (E-values for the point estimates [lower limits of the CI] were 2.90 [3.32), 1.54 [1.92), and 2.09 [2.39) for mortality, MACE, and MAKE, respectively)

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The study also highlighted that adverse effects were reported in approximately 50% of the cohort during follow-up, with gastrointestinal symptoms being the most commonly reported adverse effects, including nausea and vomiting