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Despite its favorable safety profile, limitations include poor systemic bioavailability and batch-to-batch variability, which are partly addressed through nanoformulation strategies

Standard IGF-1 requires multiple daily injections to maintain therapeutic levels, while IGF-1 LR3 can be administered once daily or every other day depending on protocol design

To test the protective effects of nanocarriers against CK-induced permeability changes the donor compartments were treated with CK during the 24-h permeability assays