The term ferroptosis was formally proposed in 2012, with mechanistic studies demonstrating erastins dual action in HT-1080 fibrosarcoma models: mitochondrial voltage-dependent anion channel (VDAC) modulation and inhibition of the Xc system subunit solute carrier family 7 member 11 (SLC7A11), leading to glutathione depletion and iron-dependent lipid ROS accumulation ( A pivotal 2014 study established glutathione peroxidase 4 (GPX4) as the central regulator of ferroptosis, with therapeutic implications validated in tumor xenografts (Yang et al., 2014)
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GLP-1 receptor agonists in the treatment of type 2 diabetesState-of-the-art
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The current evidence indicates promising potential, however a broader validation is required, specifically in the context of PsA
Tailoring a molecule to this specific purpose requires a substantial understanding of how the current class of GLP-1R agonists access and interact with the satiating and aversive neuronal receptor populations
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