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[1] Downstream Effects on Bone and Mineral Metabolism Elevated GH and IGF-1 have direct effects on the kidney, bone, and gut that overlap with vitamin D's own signaling pathways

HMB for Muscle Retention During Weight Loss In dieters, 3 g/day HMB maintained 70-80% more lean mass over 8 weeks compared to placebo, critical for those on GLP-1s who face accelerated catabolism

Pupils, color vision, and contrast sensitivity testing were all normal or unremarkable

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This can be caused by malnutrition, decreased absorption of thiamine by the gastrointestinal tract, a reduction in stored thiamine due to liver disease, or a combination of these factors