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When initiating combination therapy, the choice between simultaneous initiation and sequential add-on therapy remains a clinical consideration

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In more intensive therapy scenarios (such as for chronic fatigue or recovery support), a practitioner might recommend a series of daily injections over 5-10 days at 100-250 mg per day, then taper to a maintenance schedule

doi: 10.1111/dom.12993

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This can increase vulnerability to certain electrophilic toxins and smoke-derived carcinogens, especially when exposures are high and other defences are stressed