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10 In the 1960s, scientists gradually elucidated the specific steps of methionine metabolism, revealing that methionine enters the methylation pathway via SAM, is then converted to Hcy through SAH, and subsequently re-enters the methionine cycle through remethylation reactions

This is a theoretical rather than documented concern with Pendulum specifically, but it is worth monitoring INR more frequently during the first month if you take warfarin

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