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Chemotherapy-induced peripheral neuropathy: a current review

It has been proposed that during mobilization cytochrome c detaches from the IMM and dissociates from the membrane phospholipid cardiolipin

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This creates feed-forward cycles that exacerbate cuproptosis: mtROS oxidize cytosolic GSH, releasing bound Cu, and may upregulate the copper importer CTR1 via pathways such as NF-B, increasing copper influx [65]

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