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Retatrutide is an active compound released by Eli Lilly in June 2023

In the pancreas, GLP-1 mediates the insulin secretory response to glucose ingestion with the direct activation of GLP-1Rs on beta cells and through paracrine mechanisms involving vagal afferents

A recent New England Journal of Medicine study showed that although both these new drugs are highly effective, tirzepatide was shown to be more effective for weight loss, possibly because of the combination of these two hormone agonists when compared to the single hormone agonist in semaglutide

Healthcare providers should conduct comprehensive medical history assessment, including family history of thyroid cancer, before prescribing tirzepatide