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ELISA assays showed that BV2-metformin-loaded PLGA lowered pro-inflammatory markers (TNF-, IL-6) and boosted anti-inflammatory markers (IL-4, IL-10) in both the brain tissue and blood samples 19

The relationship between diet and thyroid function is a topic of intense interest

PMID 16246122

A key innovation in this field is the development of designer probioticsgenetically engineered or otherwise modified commensal bacterial strains specifically tailored to withstand production stresses such as lyophilization, thermal fluctuations, and gastric acidity, or to enhance their most beneficial functions for the host (537)

Weizmann Institute of Science

That's better than nothing, but it's not the same as Phase 2 safety data