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Which molecule regenerates reduced glutathione (GSH) from oxidized glutathione (GSSG)

La baisse du GSH est la fois une consquence et un amplificateur du vieillissement : l'accumulation de dommages oxydatifs rduit la capacit de synthse, tandis que la dpltion en glutathion laisse les cellules plus vulnrables aux agressions suivantes

Thus, HepG2 cells and other immortalized cell lines should be used with caution

doi: 10.3390/md12042019

Both aging and neurodegenerative disorders, such as ALS, share a multifactorial process underlying their progressive evolution, which is genetically determined and epigenetically influenced by the environment

This latter finding is particularly important given the possibility that cerebral hypoperfusion may act as a precursor to the development of mild cognitive impairment (MCI), a condition that often precedes the onset of AD [46]