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As a result, we studied the continuous measure of time to response as the primary clinical outcome of interest, and used the cross-sectional remission criterion as a secondary measure of interest

However, knocking out FAP expressing fibroblasts in mice did not suppress inflammation but reduced the extent of tissue damage, confirming the pathogenic role of FAP in arthritis

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This uncertainty may reflect limitations in statistical power, particularly for MR-Egger, which requires stronger assumptions and larger sample sizes to detect causal effects

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