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Figures 2, 4) availability is maintained by de novo synthesis from precursor amino acids, (glutamate, cysteine, and glycine), reduction of GSSG by glutathione reductase (GR), and uptake from exogenous GSH sources across plasma membranes (Figure 4) (62, 63)

GSH is synthesised de novo from glutamate, cysteine and glycine [13] with a -carboxyl linkage between glutamate and cysteine of GSH, which is only susceptible to hydrolysis by glutamyltranspeptidase, [14] rather than the usual -carboxyl group

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However, allow 4-6 weeks off for receptor resensitization

Can be used daily from the start

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