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These hallmarks, while valuable for liver hepatocyte applications, severely limit the use of these LNP technologies beyond the liver

Factors like the type of peptide used, the application method (topical vs

Biomed Pharmacother 89:19

Excessive ROS may change the mitochondrial membrane potential (MMP) by regulating the ratio of pro-/anti-apoptosis factors, which leads to the release of Cyt c from the mitochondria into the cytosol (Circu and Aw, 2010