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Based on limited human pharmacology data, ipamorelin appears relatively selective, with less pronounced effects on cortisol and prolactin secretion compared with some other GH secretagogues though this selectivity has not been extensively validated in large human trials

The disruption extends beyond direct receptor binding-EED exposure significantly impairs recruitment of critical coactivators such as steroid receptor coactivator-1 (SRC-1), substantially weakening AR transcriptional capacity (35)

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