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These results should be interpreted as hypothesis-generating structural evidence, rather than direct experimental confirmation of nicotineprotein interactions

Mild soreness at the injection site is the most common report

[Note: Four weeks was selected as the optimal time point representing advanced disease because our previous experience with this model has demonstrated that at 4 weeks, primary tumours are well established, and the cancer has metastasised

Crit Rev Biochem Mol Biol 48(2):173181 Rigobello MP, Bindoli A (2010) Mitochondrial thioredoxin reductase: purification, inhibitor studies, and role in cell signaling