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Restoration of mitochondrial NAD(+) levels delays stem cell senescence and facilitates reprogramming of aged somatic cells

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This route supports the predictable use of peptide drugs for endocrine disorders, immune modulation, tissue repair, and neurologically targeted interventions

10.1074/jbc.M112.393140 5 BengaGh

Throughout these disease processes, ROS-mediated impairment of antioxidant defense systems and pro-survival pathways further amplifies the neurodegeneration cascade [339]

In addition, zinc plays a vital role in the thyroid hormones metabolism by regulating thyrotropin-releasing hormone (TRH) and TSH synthesis and modulating the structures of essential transcription factors involved in synthesizing thyroid hormones (177, 178)