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While this decline can be part of normal adaptive aging, it may become clinically relevant when combined with chronic circadian disruption, neurodegenerative processes, metabolic disease, or persistent oxidative and inflammatory stress

39 ASCT1 and ASCT2, which have mainly been studied in the context of glutamine dependence, are expressed at high levels in different cancer types, 40,41,42 prompting these transporters to be considered putative therapeutic targets in cancer, with different inhibitors currently under investigation

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The second is GIP , which plays a role in fat storage and insulin response