Abbasinejad at Cape Fear Physical Medicine takes a personalized approach to weight loss, offering Ozempic as a GLP-1 medication for patients seeking to manage their weight
The pills havent been compared head-to-head in a clinical trial, but in separate studies, the Wegovy pill showed average weight loss of 14% over 64 weeks, compared with 2% for a placebo, while orforglipron showed 11% weight loss over 72 weeks on its highest dose, compared with 2% for the placebo group
Standard daily dosing protocol Most compounding pharmacies and prescribing providers recommend once-daily dosing for sublingual GLP-1 drops
These populations already face elevated bone loss risk, and adding GLP-1 therapy without calcium and vitamin D supplementation multiplies that risk substantially
Second, this analysis focused exclusively on a subset of GLP-1 RA therapies (specifically semaglutide and tirzepatide) and did not account for other common PCOS treatments, such as metformin, combined oral contraceptives, or anti-androgen therapies
Some describe microdosing as helpful during transitions, such as restarting after a break or adjusting due to side effects
