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Accordingly, this mechanism would circumvent the blocking of distinct NMDA receptors in the brainstem that might otherwise increase food intake in response to MK-801

Last reviewed: May 14, 2026 Last updated: May 14, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

A recent article has suggested that appetite suppression may make it hard for some athletes to eat enough for all of their caloric and nutritional needs, so special care should be taken by athletes on GLP-1s

Beyond weight loss, retatrutide has shown promise in improving insulin resistance, reducing visceral fat and potentially increasing overall energy expenditure

The recently completed Phase 3 TRIUMPH-4 trial confirmed this, showing 28.7% average weight loss (71.2 lbs) at 68 weeks with the weekly 12 mg dose

Vitamin B-12 Supports normal metabolic and neurological function and is commonly included in wellness-focused formulations