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da Cruz Alves NM, Pfrimer K, Santos PC, de Freitas EC, Neves T, Pessini RA, et al

In this context, a post-hoc subgroup analysis of the multicenter, randomized, double-blind, placebo-controlled VITATOPS trial (49) proposed that the small benefit of homocysteine-lowering by B vitamins might be canceled in patients treated with antiplatelet drugs (50)

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APOE4 = Apolipoprotein E epsilon 4 allele