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The key difference may be that endurance athletes more acutely feel the effects of suboptimal B12 levels during long training sessions
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The Nrf2 activity remains suppressed under physiological conditions due to its degradation via ubiquitination and proteasomal pathways
Li Y, Perry T, Kindy MS, Harvey BK, Tweedie D, Holloway HW, Powers K, Shen H, Egan JM, Sambamurti K, Brossi A, Lahiri DK, Mattson MP, Hoffer BJ, Wang Y, Greig NH (2009 Jan 27) GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism
Importantly, THC shows an excellent safety profile: acute toxicity studies revealed no adverse effects at doses up to 10,000 mg/kg [13], while sub-chronic administration (400 mg/kg) caused no significant toxicological findings [18]
In fact, many people regularly get injections with vitamin B12
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