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doi: 10.1016/j.ecoenv.2022.114190 116

Errors in any of these steps can affect the potency and effectiveness of the compound

demonstrated that a combined treatment of GIP and GLP-1 for 12 days in Swiss mice resulted in increased weight loss compared to treatment with exendin-4 alone but had no additional blood glucose regulation benefits (33)

The other complicating factor can be patients who really cant afford to lose weight (yes this is a real factor in some patients a rarity - but common in my patients) - so there we need to go with a less potent GLP and then look at Rx of Trulicity, but then dose splitting to keep costs down, and still give a decent brain level

Watch for thyroid swelling or discomfort

Aim for at least 150 minutes of moderate-intensity exercise per week to improve insulin sensitivity and overall health