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Eligible patients were being treated or observed as outpatients and had moderate to severe fatigue, defined as a response of somewhat, quite a bit, or very much to the FACIT-F question I feel fatigued. Patients were stratified according to sex, Eastern Cooperative Oncology Group (ECOG) performance status (PS

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However, in case of persistent and/or larger ER stress prevailing over the cellular defensive mechanisms, cell injury and activation of various pro-apoptotic signaling pathways take place (Oyadomari and Mori, 2004