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Research suggests GIP agonism also amplifies the weight loss effects of GLP-1, which explains why dual-agonists like tirzepatide outperform single-agonists like semaglutide

Available from Accessed 23 July 2024 Ethics declarations Data availability The datasets presented in this article are not readily available due to legal restrictions on sharing the dataset as regulated by the Valencia regional government by means of legal resolution by the Valencia Health Agency [2009/13312] which forbids the dissemination of data to third parties (accessible at: Upon request, authors can allow access to the databases to verify the accuracy of the analysis or the reproducibility of the study

GLP-1s are changing the cardiovascular landscape

GLP-1s also act on the central nervous system, particularly the brainstem and hypothalamus, where it regulates satiety and appetite

This is a key distinguishing factor in the Mounjaro vs Trulicity debate

Key Takeaway: Wellness is not about one "magic" ingredient