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This inflammatory response associated with TMAO is also seen in conditions such as psoriatic arthritis (PsA)

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Proteomic analyses have identified altered exosomal protein profiles in patients with HT showing notable upregulation of proteins like hepatocyte growth factor-like protein (HGFL), focal adhesion kinase 1 (FAK1), and tyrosine-protein phosphatase non-receptor type 12 (PTPN12), and downregulation of proteins including proteasome inhibitor PI31 subunit (PSMF1) and cystatin-M (CYTM) playing key roles in regulating processes related to inflammation, immune response and proliferation [28]

Interestingly, oral vitamin B 12 replacement therapy was also effective for the patients with a history of gastrectomy