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The further oxidative activation of carcinogens leads to the development of electrophilic reactive intermediates, which bind to DNA and cause mutation

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Specifically, among treatment agents, Schisandra chinensis extract demonstrated the largest effect size, accompanied by a concomitant reduction in heterogeneity [SMD = 4.99, 95% CI (3.56, 6.41), I 2 = 0.0%, p = 0.927]

Design of selective and soluble inhibitors of tumor necrosis factor- converting enzyme (TACE)