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The Food and Drug Administration (FDA) approved semaglutide as a 31-amino acid synthetic peptide in 2017, which led to its rapid market adoption

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Future perspectives In summary, the cardiovascular safety of all currently marketed GLP-1 RAs has been thoroughly established in large CVOTs (Sattar et al., 2021), of which some also suggested a substantial cardioprotective benefit

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It is classified as a receptor agonist that targets pathways linked to glucagon receptor activity, glucagon like peptide-1 GLP-1, and glucose dependent insulinotropic polypeptide GIP

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