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Tirzepatide has become the primary research tool for studying what GIPR agonism contributes to metabolic biology when added to GLP-1R activation establishing the pharmacological basis of dual incretin superiority over GLP-1R monoagonism that has been validated across the SURPASS clinical trial programme

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While it is true that the United States has the largest GLP-1 market in the world, data from the last few years shows that GLP-1s have become popular in other markets such as the United Kingdom, who is currently leading the European market with their rise in NHS Ozempic Prescriptions

Orforglipron (Foundayo) is expected to be available later this year in the UK, although timelines may change

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