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Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes

10.1016/j.neuropharm.2019.02.020 61 VallfD.KalafateliA

Real-World Evidence A study published in JAMA Internal Medicine analyzed 18,386 adults who are overweight or with obesity in real-world clinical settings

While it is hypothesised that such changes could potentially contribute to headaches in some individuals, this relationship has not been firmly established in clinical studies

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particularly nausea and vomiting to support treatment continuity