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Concomitantly, reduced renal clearance of insulin and glucagon in AKI results in an elevated glucagon/insulin ratio, which triggers hepatic cAMP/PKA pathway and promotes gluconeogenesis ( 5 Intervention and treatment of mitochondrial energy metabolic reprogramming in AKI 5.1 Mitochondrial-targeted peptide D-Arg-dimethylTyr-Lys-Phe-NH2 (SS-31) The mitochondrial-targeted peptide SS-31 has demonstrated significant protective effects in renal tubular cells by attenuating OS, thereby reducing apoptosis and necrosis (Zuo et al., 2020

Cold Spring Harb Perspect Biol 6 , a019133, (2014)

DOI: BMC Med 14, 103 (2016)

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& Misteli, T