Vitamin B12 is a nutritional aid that keeps blood and nerve tissues healthy and helps to generate DNA, the gene of every cell
NAD+ plays a significant role in activating certain enzymes to repair DNA damage that occurs because of stress, aging, and environmental factors
Simultaneously, NNMT inhibition preserves SAM the primary methyl-donor for epigenetic histone and DNA methylation reactions which has been shown to influence gene expression programmes governing adipogenesis, lipid storage, and energy expenditure in adipose tissue models
Conversely, SIM1 overexpression reduces food ingestion and body weight in mice fed a high-fat diet, acting downstream of melanocortin receptors [70]
Treatment Details
| | Intensive Performance Protocol | 10mg subcutaneous, 5x/week (weekdays) | 150mg oral, daily | Both compounds AM, pre-training | 6 weeks on, 4 weeks off | Athletic performance research, substrate utilization studies, endurance capacity trials | Higher dosing frequency and dose intensity produce more pronounced short-term shifts in RER and VO2 max, but require stricter adherence and increase washout sensitivity
