Park EJ, Park YJ, Lee SJ, Lee K, Yoon C
M.Vzquez-CarradaM.Uribe-RamrezD.Matuz-MaresD
ROS and RNS production are facilitated by pattern recognition receptors [C-reactive protein (CRP), toll-like receptors] capable of recognizing pathogen (bacterial/viral)-associated molecular patterns and/or damage-associated molecular patterns in apoptotic or damaged cells (92100) (Figure 6)
Both SLE patient serum and RSL-3 treatment significantly reduced the viability of normal neutrophils, while treatment with liproxstatin-1 (LPX-1) and iron chelator deferoxamine (DFO) rescued neutrophil death induced by SLE patient serum, suggesting that ferroptosis is the major form of neutrophil death in SLE [27]
O., Ziegler, M
That makes the contribution of GHK-Cu specifically to any reported endpoint difficult to attribute, and is one of the reasons independent reviewers do not regard the human evidence base as conclusive