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Blum et al (2003) presented a new family of bioisostere inhibitors, based on the structure of AG 538, a tyrphostin inhibiting the IGF-1R TK at the substrate level and not at the ATP binding site (Blum et al, 2000)
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\Low Immunogenicity: Did not lead to antibody formation in studies up to 24 weeks (Human Study)
Certain medications may also interfere with absorption and cause deficiency, in particular, medicines prescribed for heartburn, antibiotics, blood pressure medicine, cholesterol-lowering drugs, diabetes medications and antipsychotic drugs