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Choosing the wrong solvent wont necessarily ruin a peptide, but misunderstanding their roles can lead to incorrect assumptions about stability

Veys KR, Elmonem MA, Arcolino FO, van den Heuvel L, Levtchenko E (2017) Nephropathic cystinosis: an update

In addition, the study sample size was small

[4] 2-meOE 2 has a higher binding affinity for sex hormone-binding globulin (SHBG) than E 2 and 2-OH-E 2 and has no affinity for the estrogen receptor