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Although many mitochondria-related mechanisms still have to be investigated, and whether they are the cause or consequence of this disorder is still unknown, the accumulating data show that the breakdown of any of the mitochondrial functions may contribute to abnormal brain development leading to ASD

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It is also noted that the GH pulses are more equally distributed throughout 24 hours of sleep deprivation compared to a night-time sleep condition, with large individual pulses occurring during the day (478)