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The removal of acetyl groups by HDACs leads to the condensation of chromatin, making the DNA more tightly wound around histone proteins [259]

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In an interesting study of the lymphoid elements infiltrating halo nevi, oligoclonal expansion of T cells was observed in all patients, and in one patient, T cells using the same TCR beta chain were observed in distinct halo nevi, demonstrating a local expansion of common clones that are most likely activated by shared antigens within the nevi (336)

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