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10.1182/blood.2019000944 36 MaJ.LiY.YangX.LiuK.ZhangX.ZuoX.et al (2023)

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The increasing A aggregation also led to the release of nitric oxide, reactive oxygen species (ROS), and proinflammatory cytokines which are factors that may contribute to neuronal death ( APOE4 difference from other APOE isoforms Apolipoprotein E (APOE) is a protein that transports cholesterol and lipids

These steroidal lactones may possess intrinsic healing properties as antioxidants and anti-inflammatory compounds

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The primary endpoint rate in the overall matched population was 16% (n = 502)