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(NCN 2013/11/B and NZ2/00130)

Among the most notable are MSDC-0160 (PNU-91325) and MSDC-0602K, which show potent insulin-sensitizing effects in preclinical 52,53,54 and clinical 53,55 studies despite exhibiting much reduced ability to bind and signal via PPAR 51

AOD-9604 works by mimicking the specific fat-metabolizing action of human growth hormone without activating the full HGH receptor cascade

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HFD-fed fish exhibited the lowest crude protein and highest crude fat levels

Both dose and duration of the disturbance in the GSH redox state determine these downstream pathways and the outcome of the signaling pathway: damage versus acclimation