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After 28 days of twice-daily application, subjects showed 9% reduction in crow feet wrinkles, 11% reduction in forehead wrinkles, and 5% reduction in nasolabial folds

After a mean of 9.3 years, the recurrence of postoperative curvature had increased from 0% after a mean of 38 months (1873 months) to 23.7%, post-op erectile dysfunction increased from 3.0% to 39.5%, penile shortening from 0.0% to 65.8%, and impairment of penile sensitivity from 3% to 31.4%

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Discussion with case patient's physician MTHFR 677 and 1298 polymorphisms have an equivocal association with risk for venous thrombosis

2019;doi:10.1093/rheumatology/kez308

Takeaway: Its a potential helper, but lifestyle changes (visceral fat loss) are still the heavy lifters