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Higher pheomelanin will make skin look brighter and lighter-toned while increased eumelanin makes skin darker

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and (2) IGF-1Eb (rodents)/IGF-1Ec (humans) the mechanically-induced, locally expressed isoform from which Mechano Growth Factor (MGF) is produced after proteolytic cleavage of its unique E-domain

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It prevents progression of anemia and nerve damage by supplying B directly, even when intrinsic factor (the gastric protein needed for oral B12 absorption) is lacking

doi:10.1016/S0140-6736(85)91677-0 12