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Three receptor pathways means three separate adaptation processes happening simultaneously, and rushing any one of them creates problems

Currently, the known physiological functions of selenium in the human body are primarily associated with selenoproteins containing selenocysteine residues, with over 25 types identified [25]

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Physiol Rev 63(4):14201480

Meyerhoff O, Mller K, Roelfsema MRG, Latz A, Lacombe B, Hedrich R, Dietrich P, Becker D (2005) AtGLR3.4 , a glutamate receptor channel-like gene, is sensitive to touch and cold