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[75] and McCullumsmith et al

As a woman in midlife who has seen how simply bending down to unload the dishwasher can result in me tweaking my back, I know Im not alone in this: Up-and-down estrogen levels can bring on all sorts of joint discomfort for women during this period of life

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Eur J Clin Pharmacol 1989

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They play roles in the recovery of the gastric and intestinal cells from injury, they promote cell migration in order to close-off the site of an injury and they prevent leakage of the gastrointestinal contents into the bloodstream