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The increase in nitric oxide is particularly intriguing since alpha-1 antitrypsin has been shown to inhibit iNOS, nitric oxide release and NF-kB activation, suggesting that alpha-1 antitrypsin replacement therapy or other neutrophil elastase inhibitor therapies may help decrease oxidative stress and inflammation

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They may change appetite, body weight, digestion, and sometimes thyroid lab values, which can all influence how a patient feels and how their thyroid medication works

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