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In addition, the SOCS gene is activated by GH signaling and works as a short intracellular negative feedback loop which rapidly down-regulate GHR activity by internalization and receptor ubiquitinoylation resulting in lysosomal and proteasomal degradation (101)

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2024;10:e23543 Jiang H, Zheng B, Hu G, Kuang L, Zhou T, Li S, et al

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