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With a needle-free syringe, 100 L of insulin or saline were injected into alternate nostrils for a total administration volume of 400 L

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SREBP-2 silencing significantly decreased the expression of HMGCR , SQLE , LXR , CYP7A1 , and PCSK9 genes, while increasing LDLR gene expression compared to nontransfected control cells (Fig