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Although calpain-1 is implicated in cytoskeletal breakdown, its genetic ablation does not alter erythrocyte lifespan, indicating possible compensatory mechanisms (Wieschhaus et al., 2012)

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PMID 5642099

Ginsenoside upregulates GPX4 to mitigate oxidative stress induced by 6-hydroxydopamine (Lee et al., 2020)

Metformin is not FDA-approved for weight loss.